Technology of deep brain stimulation: current status and future directions

JK Krauss, N Lipsman, T Aziz, A Boutet… - Nature Reviews …, 2021 - nature.com
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model

J Tasserie, L Uhrig, JD Sitt, D Manasova, M Dupont… - Science …, 2022 - science.org
Loss of consciousness is associated with the disruption of long-range thalamocortical and
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …

Neural signatures of hyperdirect pathway activity in Parkinson's disease

A Oswal, C Cao, CH Yeh, WJ Neumann… - Nature …, 2021 - nature.com
Parkinson's disease (PD) is characterised by the emergence of beta frequency oscillatory
synchronisation across the cortico-basal-ganglia circuit. The relationship between the …

Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease

AS Ríos, S Oxenford, C Neudorfer, K Butenko… - Nature …, 2022 - nature.com
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

Deep brain stimulation targets in epilepsy: systematic review and meta‐analysis of anterior and centromedian thalamic nuclei and hippocampus

A Vetkas, A Fomenko, J Germann, C Sarica… - …, 2022 - Wiley Online Library
Deep brain stimulation (DBS) is a neuromodulatory treatment used in patients with drug‐
resistant epilepsy (DRE). The primary goal of this systematic review and meta‐analysis is to …

Dynamic coupling of whole-brain neuronal and neurotransmitter systems

ML Kringelbach, J Cruzat, J Cabral… - Proceedings of the …, 2020 - National Acad Sciences
Remarkable progress has come from whole-brain models linking anatomy and function.
Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human …

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

N Li, JC Baldermann, A Kibleur, S Treu… - Nature …, 2020 - nature.com
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …