The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay
detects DNA breakage by labeling the free 3ʹ-hydroxyl termini. Given that genomic DNA …

Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9
nuclease system has allowed the generation of disease models and the development of …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Tumors arise from the transformation of normal stem cells or mature somatic cells.
Intriguingly, two types of tumors have been observed by pathologists for centuries: well …

Disorder and noise are inherent in biological systems. They are required to provide systems
with the advantages required for proper functioning. Noise is a part of the flexibility and …