The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse
range of underlying dominant disease processes and pathways despite apparent similarities …

Airway hyper‐responsiveness (AHR) has long been considered a cardinal feature of
asthma. The development of the measurement of AHR 40 years ago initiated many …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

Asthma affects over 300 million people worldwide and its prevalence is increasing. COPD is
the third leading cause of death globally. Asthma and COPD are complex inflammatory …

The pathogenesis of asthma includes a complex interplay among airway inflammation,
hyperresponsiveness, and remodeling. Current evidence suggests that airway structural …

Known to have affected around 340 million people across the world in 2018, asthma is a
prevalent chronic inflammatory disease of the airways. The symptoms such as wheezing …

Aging is associated with a dysregulation of the immune system, leading to a general pro-
inflammatory state of the organism, a process that has been named inflamm-aging …