Male infertility
A Agarwal, S Baskaran, N Parekh, CL Cho, R Henkel… - The Lancet, 2021 - thelancet.com
It is estimated that infertility affects 8–12% of couples globally, with a male factor being a
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo
BACKGROUND Knowledge of the proteomic composition of the gametes is essential to
understand reproductive functions. Most of the sperm proteins are related to …
understand reproductive functions. Most of the sperm proteins are related to …
Energy metabolism in mammalian sperm motility
A Amaral - WIREs mechanisms of disease, 2022 - Wiley Online Library
Mammalian sperm, the only cells that achieve their purpose outside their organism of origin,
have to swim vigorously within the female reproductive tract to reach an oocyte. Flagellar …
have to swim vigorously within the female reproductive tract to reach an oocyte. Flagellar …
[PDF][PDF] Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia
Reduced sperm motility, defined as asthenozoospermia, is a frequent cause of male
infertility, and is mainly connected with the dysfunction of sperm mitochondria. The aim of …
infertility, and is mainly connected with the dysfunction of sperm mitochondria. The aim of …
[HTML][HTML] Proteomic analyses of human sperm cells: understanding the role of proteins and molecular pathways affecting male reproductive health
A Agarwal, MK Panner Selvam, S Baskaran - International Journal of …, 2020 - mdpi.com
Human sperm proteomics research has gained increasing attention lately, which provides
complete information about the functional state of the spermatozoa. Changes in the sperm …
complete information about the functional state of the spermatozoa. Changes in the sperm …
Proteomics of human spermatozoa
Proteomic methodologies offer a robust approach to identify and quantify thousands of
proteins from semen components in both fertile donors and infertile patients. These …
proteins from semen components in both fertile donors and infertile patients. These …
[HTML][HTML] Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals
X Cao, Y Cui, X Zhang, J Lou, J Zhou, H Bei… - Reproductive Biology …, 2018 - Springer
Asthenozoospermia is considered as a common cause of male infertility and characterized
by reduced sperm motility. However, the molecular mechanism that impairs sperm motility …
by reduced sperm motility. However, the molecular mechanism that impairs sperm motility …
Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility
K Xu, L Yang, L Zhang, H Qi - Development, 2020 - journals.biologists.com
The development and maintenance of the correct morphology of sperm is important for their
functions. Cellular morphogenesis of sperm occurs during the post-meiotic developmental …
functions. Cellular morphogenesis of sperm occurs during the post-meiotic developmental …
[HTML][HTML] Characterization of the sperm proteome and reproductive outcomes with in vitro, fertilization after a reduction in male ejaculatory abstinence period
ZQ Shen, B Shi, TR Wang, J Jiao, XJ Shang… - Molecular & Cellular …, 2019 - ASBMB
Semen samples from men after a short ejaculatory abstinence show improved sperm quality
and result in increased pregnancy rates, but the underlying mechanisms remain unclear …
and result in increased pregnancy rates, but the underlying mechanisms remain unclear …
[HTML][HTML] Antioxidants present in reproductive tract fluids and their relevance for fertility
Nowadays, infertility is classified as a disease of the reproductive system. Although it does
not compromise the life of the individual, it can have detrimental effects on the physiological …
not compromise the life of the individual, it can have detrimental effects on the physiological …