The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation, which is a curative therapy for numerous diseases including …

The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology
under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show …

Sickle cell disease (SCD) is the most common serious monogenic disease with 300,000
births annually worldwide. SCD is an autosomal recessive disease resulting from a single …

The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to
fully realize the potential of HSPC-based therapies. In particular, the application of clinically …

Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

Nonspecific protein adsorption impedes the sustainability of materials in biologically related
applications. Such adsorption activates the immune system by quick identification of …

The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …

Human pluripotent stem cells (hPSCs) provide powerful resources for application in
regenerative medicine and pharmaceutical development. In the past decade, various …