There has been increasing awareness that glioblastoma, which may seem
histopathologically similar across many tumors, actually represents a group of molecularly …

There are mainly two types of short RNAs that target complementary messengers in animals:
small interfering RNAs and micro-RNAs. Both are produced by the cleavage of double …

Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also
nonspecific to brain stroma. These are major limitations in the effective treatment of brain …

Bone marrow–derived multipotent mesenchymal stroma cells (MSCs) have emerged as
cellular vectors for gene therapy of solid cancers. We implanted enhanced green fluorescent …

Our objective is to assess treatment efficacy, safety and pattern of response and recurrence
in patients with recurrent high-grade glioma treated with bevacizumab and irinotecan. We …

The prognosis of patients with glioblastoma, anaplastic astrocytoma, and anaplastic
oligodendroglioma remains poor despite standard treatment with radiotherapy and …

Glioblastoma is an aggressive brain tumor with a dismal prognosis. Gene therapy may offer
a new option for the treatment of these patients. Several gene therapy approaches have …

Malignant primary glial and secondary metastatic brain tumors represent distinct
pathological entities. Nevertheless, both tumor types induce profound angiogenic responses …

Gliomas are the most frequent primary tumors of the central nervous system in adults.
Glioblastoma multiforme, the most aggressive form of astrocytic tumors, displays a rapid …

Yu Cheng, Joseph D. Meyers, Richard S. Agnes, Tennyson L. Doane, Malcolm E. Kenney,
Ann-Marie Broome,* Clemens Burda,* and James P. Basilion* the blood with reduced …