The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and Therapeutic Perspective
Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a pressing
global health concern. Its remarkable ability to intertwine with cellular processes, from …
global health concern. Its remarkable ability to intertwine with cellular processes, from …
Emerging drugs for the treatment of herpetic keratitis
Introduction Herpes simplex keratitis stands as a prominent factor contributing to infectious
blindness among developed nations. On a global scale, over 60% of the population tests …
blindness among developed nations. On a global scale, over 60% of the population tests …
Seneca Valley virus 3C protease cleaves OPTN (optineurin) to Impair selective autophagy and type I interferon signaling
J Song, Y Guo, D Wang, R Quan, J Wang, J Liu - Autophagy, 2024 - Taylor & Francis
Seneca Valley virus (SVV) causes vesicular disease in pigs, posing a threat to global pork
production. OPTN (optineurin) is a macroautophagy/autophagy receptor that restricts …
production. OPTN (optineurin) is a macroautophagy/autophagy receptor that restricts …
[HTML][HTML] Tolerability, pharmacokinetics, and anti-herpetic activity of orally administered BX795
Herpes simplex viruses type-1 (HSV-1) and type-2 (HSV-2) are ubiquitous human
pathogens causing serious pathologies in the ocular, orofacial and anogenital regions …
pathogens causing serious pathologies in the ocular, orofacial and anogenital regions …
[HTML][HTML] Age-related effects of optineurin deficiency in the mouse eye
CC Su, C Liu, V Adi, KC Chan, HC Tseng - Vision Research, 2024 - Elsevier
Optineurin (OPTN) is a gene associated with familial normal tension glaucoma (NTG). While
NTG involves intraocular pressure (IOP)-independent neurodegeneration of the visual …
NTG involves intraocular pressure (IOP)-independent neurodegeneration of the visual …
[HTML][HTML] Rapid NETosis is an effector mechanism to combat ocular herpes infection
Purpose: Neutrophils are known mediators of innate immunity, yet their effector function in
herpesvirus infections remains poorly understood. Here, we elucidate the mechanistic action …
herpesvirus infections remains poorly understood. Here, we elucidate the mechanistic action …
[HTML][HTML] HerpDock: A GUI-based gateway to HSV-1 molecular docking insights
Abstract Herpes Simplex Virus 1 (HSV-1) is a member of the alpha-Herpesviridae family,
with over 60% of the global population being seropositive. HSV-1 can cause a range of …
with over 60% of the global population being seropositive. HSV-1 can cause a range of …
From homeostasis to defense: Exploring the role of selective autophagy in innate immunity and viral infections
M Huang, W Zhang, Y Yang, W Shao, J Wang… - Clinical …, 2024 - Elsevier
The process of autophagy, a conservative evolutionary mechanism, is responsible for the
removal of surplus and undesirable cytoplasmic components, thereby ensuring cellular …
removal of surplus and undesirable cytoplasmic components, thereby ensuring cellular …
Optineurin in ocular herpes infection
E Grinage, D Shukla - Experimental eye research, 2022 - Elsevier
Abstract Herpes Simplex Virus-1 (HSV-1) is a neurotropic virus that can infect humans in the
eye and travel to the trigeminal ganglion to establish latency. HSV-1 causes various disease …
eye and travel to the trigeminal ganglion to establish latency. HSV-1 causes various disease …
Tunneling Nanotubes: The Cables for Viral Spread and Beyond
Multicellular organisms require cell-to-cell communication to maintain homeostasis and
thrive. For cells to communicate, a network of filamentous, actin-rich tunneling nanotubes …
thrive. For cells to communicate, a network of filamentous, actin-rich tunneling nanotubes …