The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Tetracyclines possess many properties considered ideal for antibiotic drugs, including
activity against Gram-positive and-negative pathogens, proven clinical safety, acceptable …

Gram-negative bacteria express a plethora of efflux pumps that are capable of transporting
structurally varied molecules, including antibiotics, out of the bacterial cell. This efflux lowers …

Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a
worldwide health problem. The continuous dissemination of 'multidrug-resistant'(MDR) …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for
the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and …

Resistance trends have changed greatly over the 14 years (1997–2011) whilst I was
Director of the UK Antibiotic Resistance Monitoring and Reference Laboratory (ARMRL) …

Tigecycline (TIG) exhibits broad-spectrum activity against many Gram-positive and Gram-
negative pathogens. However, clinical resistance has emerged recently and has been …

Multidrug efflux pumps constitute a group of transporters that are ubiquitously found in any
organism. In addition to other functions with relevance for the cell physiology, efflux pumps …