Cancer represents an evolutionary process through which growing malignant populations
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …

The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …

Myelodysplastic syndromes (MDS) are clonal haematopoietic stem cell (HSC) disorders
predominating in the elderly, characterised by ineffective haematopoiesis leading to blood …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …

Summary VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a
pleiotropic, severe autoinflammatory disease caused by somatic mutations in the ubiquitin …

Current objectives regarding treatment of acute myeloid leukemia (AML) include achieving
complete remission (CR) by clinicopathological criteria followed by interrogation for the …

Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Sterile tissue injury is thought to locally activate innate immune responses via damage-
associated molecular patterns (DAMPs). Whether innate immune pathways are remotely …