Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options
and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in …

Most of the cholesterol in plasma is in an esterified form that is generated in potentially
cardioprotective HDLs. Cholesteryl ester transfer protein (CETP) mediates bidirectional …

Background: The high-density lipoprotein hypothesis of atherosclerosis has been
challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which …

Inflammation plays a central role in the development of asthma, which is considered an
allergic disease with a classic Th2 inflammatory profile. However, cytokine IL-17 has been …

Rationale: High-density lipoprotein (HDL) cholesterol (HDL-C) levels decline during sepsis,
and lower levels are associated with worse survival. However, the genetic mechanisms …

In this study, we investigated the therapeutic potential of lentinan in mouse models of
inflammatory bowel disease (IBD) and colitis‐associated cancer (CAC). Lentinan decreased …

Background Weight loss in patients with metabolic syndrome has positive effects on
cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid …

Plasma cholesteryl ester transfer protein (CETP) activity diminishes HDL-cholesterol levels
and thus may increase atherosclerosis risk. Experimental evidence suggests CETP may …

Raising HDL using cholesteryl ester transfer protein (CETP) inhibitors failed to show a
clinically relevant risk reduction of cardiovascular disease in clinical trials, inviting …