Mechanisms of substrate processing during ER-associated protein degradation
JC Christianson, E Jarosch, T Sommer - Nature Reviews Molecular Cell …, 2023 - nature.com
Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
Endoplasmic reticulum–associated protein degradation
L Krshnan, ML van de Weijer… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
H Feng, BR Stockwell - PLoS biology, 2018 - journals.plos.org
Ferroptosis is a cell death process driven by damage to cell membranes and linked to
numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is …
numerous human diseases. Ferroptosis is caused by loss of activity of the key enzyme that is …
Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
Crosstalk between mammalian autophagy and the ubiquitin-proteasome system
NM Kocaturk, D Gozuacik - Frontiers in cell and developmental …, 2018 - frontiersin.org
Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
Mass spectrometry profiling of HLA-associated peptidomes in mono-allelic cells enables more accurate epitope prediction
Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases
AL Richards, M Eckhardt, NJ Krogan - Molecular systems biology, 2021 - embopress.org
A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …
expediting the development of novel therapeutic interventions. Disease mechanisms are …
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex
INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …
A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes
Lipid droplet (LD) functions are regulated by a complement of integral and peripheral
proteins that associate with the bounding LD phospholipid monolayer. Defining the …
proteins that associate with the bounding LD phospholipid monolayer. Defining the …
Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation
V Hung, SS Lam, ND Udeshi, T Svinkina, G Guzman… - elife, 2017 - elifesciences.org
The cytosol-facing membranes of cellular organelles contain proteins that enable signal
transduction, regulation of morphology and trafficking, protein import and export, and other …
transduction, regulation of morphology and trafficking, protein import and export, and other …