In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

The vast array of cell types of multicellular organisms must individually fine-tune their
internal metabolism. One important metabolic and stress regulatory mechanism is the …

Protein N-glycosylation is ubiquitous in the brain and is closely related to cognition and
memory. Alzheimer's disease (AD) is a multifactorial disorder that lacks a clear pathogenesis …

Evidence links neuroinflammation to Alzheimer's disease (AD); however, its exact
contribution to the onset and progression of the disease is poorly understood. Symptoms of …

Fear-based disorders such as post-traumatic stress disorder (PTSD) steepen age-related
cognitive decline and double the risk for developing Alzheimer's disease (AD). Because of …

Post-translational modification (PTM) plays a critical role in increasing proteome complexity
and diversifying protein functions. O-GlcNAc modification is a reversible, dynamic and highly …

O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine
residues is a post-translational modification process that senses nutrient availability and …

Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc.
A single protein is often O-GlcNAcylated on several amino acids and the modification of a …

Neuronal activity is an energy-intensive process that is largely sustained by instantaneous
fuel utilization and ATP synthesis. However, how neurons couple ATP synthesis rate to fuel …

Background: Tauopathies are a group of neurodegenerative disorders, including
Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology …