[HTML][HTML] Host-directed therapies for bacterial and viral infections

SHE Kaufmann, A Dorhoi, RS Hotchkiss… - Nature reviews Drug …, 2018 - nature.com
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Tackling drug resistance and other causes of treatment failure in leishmaniasis

GJ Wijnant, F Dumetz, L Dirkx, D Bulté… - Frontiers in Tropical …, 2022 - frontiersin.org
Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

[HTML][HTML] Coronavirus activates an altruistic stem cell–mediated defense mechanism that reactivates dormant tuberculosis: implications in coronavirus disease 2019 …

L Pathak, S Gayan, B Pal, J Talukdar, S Bhuyan… - The American journal of …, 2021 - Elsevier
We postulate that similar to bacteria, adult stem cells may also exhibit an altruistic defense
mechanism to protect their niche against external threat. Herein, we report mesenchymal …

Mesenchymal stromal cells: an antimicrobial and host-directed therapy for complex infectious diseases

TD Shaw, AD Krasnodembskaya… - Clinical microbiology …, 2021 - Am Soc Microbiol
There is an urgent need for new antimicrobial strategies for treating complex infections and
emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells …

Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy

A Khan, L Mann, R Papanna, MA Lyu, CR Singh… - Scientific reports, 2017 - nature.com
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids,
including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose …

Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

L Dirkx, S Hendrickx, M Merlot, D Bulté… - Communications …, 2022 - nature.com
Given the discontinuation of various first-line drugs for visceral leishmaniasis (VL), large-
scale in vivo drug screening, establishment of a relapse model in rodents …

Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence

S Fatima, SS Kamble, VP Dwivedi… - The Journal of …, 2020 - Am Soc Clin Investig
Tuberculosis (TB) remains a major infectious disease worldwide. TB treatment displays a
biphasic bacterial clearance, in which the majority of bacteria clear within the first month of …

Phenotypic Heterogeneity in Mycobacterium tuberculosis

N Dhar, J McKinney, G Manina - Tuberculosis and the Tubercle …, 2017 - Wiley Online Library
The terms “genotype” and “phenotype” were coined by the botanist and geneticist Wilhelm
Johannsen at the beginning of the 20th century (1). Both words have a Greek etymology …

Anatomic and Cellular Niches for Mycobacterium tuberculosis in Latent Tuberculosis Infection

J Mayito, I Andia, M Belay, DA Jolliffe… - The Journal of …, 2019 - academic.oup.com
Latent tuberculosis has been recognized for over a century, but discovery of new niches,
where Mycobacterium tuberculosis resides, continues. We evaluated literature on M …

Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases

A Devi, I Pahuja, SP Singh, A Verma… - Cellular & Molecular …, 2023 - nature.com
Mesenchymal stem cells (MSCs) play diverse roles ranging from regeneration and wound
healing to immune signaling. Recent investigations have indicated the crucial role of these …