Cefazolin has been used for many years to treat bone and joint infections. Because of its
time-dependent antimicrobial activity, continuous infusion would potentially be beneficial …

Aims The aims of the study were a) to determine if there is evidence of saturable protein
binding of cefazolin in plasma across the range of concentrations achieved clinically …

OBJECTIVES American Congress of Obstetricians and Gynecologists recommends a single
dose of antibiotic prophylaxis before all cesarean sections (C/S). This recommendation is …

The paper presents an HPLC method for cefazolin determination in human serum. The
preparation step was based on serum protein precipitation with acetonitrile followed by …

This work describes a first population pharmacokinetic (PK) model for free and total
cefazolin during pregnancy, which can be used for dose regimen optimization. Secondly …

This article aims to document cefazolin (CFZ) plasma binding and its covariates during
pregnancy and compare these observations with previously reported observations in …

Cefazolin, a time-dependent first-generation cephalosporin with non-linear binding to
albumin, is widely recommended for antimicrobial prophylaxis during liver surgery to …

Background Hepatic cyst infection is a potentially severe complication in cystic disease.
Treatment demands effective antibiotic concentrations within the infected cyst. Objectives …

Skin and soft tissue infections (SSTIs) are suppurative microbial invasions of the epidermis,
dermis and subcutaneous tissues that induce a host response. They are characterized by …

Background: The preferred ambulatory IV therapy for cellulitis is often once-daily cefazolin
combined with once-daily oral probenecid (C+ P). However, due to a national probenecid …