Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Although transport into the nucleus mediated by the importin (IMP) α/β1-heterodimer is
central to viral infection, small molecule inhibitors of IMPα/β1-dependent nuclear import …

The natural evolution of rabies virus (RABV) provides a potent example of multiple host
shifts and an important opportunity to determine the mechanisms that underpin viral …

The order Mononegavirales includes five families: Bornaviridae, Filoviridae, Nyamaviridae,
Paramyxoviridae, and Rhabdoviridae. The genome of these viruses is one molecule of …

White spot syndrome virus (WSSV) is a serious epidemic pathogen of crustaceans and
cause severe economic losses to aquaculture. However, no commercial drugs presently …

Rabies is caused by neurotropic rabies virus (RABV), contributing to 60,000 human deaths
annually. Even though rabies leads to major public health concerns worldwide, we still do …

Membrane fusion during the entry of herpesviruses is carried out by the viral fusogen gB that
is activated by its partner protein gH in some manner. The fusogenic activity of gB is …

Rabies is a lethal disease caused by the neurotropic virus rabies virus (RABV), and it
remains an important public health problem globally. It is known that the host immune …

Viruses commonly antagonize the antiviral type I interferon response by targeting signal
transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon …

Rabies has affected mankind for several centuries and is one of the oldest known zoonoses.
It is peculiar how little is known regarding the means by which rabies virus (RABV) evades …