Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

The formation of axons and dendrites and maintenance of the neuron's vastly expanded
surface require the continuous addition of new membrane. This is achieved by membrane …

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

It is now known that proteins associated with neurodegenerative disease can spread
throughout the brain in a prionlike manner. However, the mechanisms regulating the trans …

Elevated concentrations of CO2 in seawater can disrupt numerous sensory systems in
marine fish. This is of particular concern for Pacific salmon because they rely on olfaction …

Spontaneous' mini'release occurs at all synapses, but its nature remains enigmatic. We
found that> 95% of spontaneous release in murine cortical neurons was induced by Ca2+ …

The genomes of non-bilaterian metazoans are key to understanding the molecular basis of
early animal evolution. However, a full comprehension of how animal-specific traits, such as …

Neuronal SNAREs and their key regulators together drive synaptic vesicle exocytosis and
synaptic transmission as a single integrated membrane fusion machine. Human pathogenic …

SNARE-complexes drive the fusion of membrane-bound vesicles with target membranes or
with each other (homotypic fusion). The SNARE-proteins are subdivided into Q a, Q b, Q c …

Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …