Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to
numerous structurally and functionally different chemotherapeutic agents. MDR is …

Development of parameters for the fabrication of nanosized vectors is pivotal for its
successful administration in therapeutic applications. In this study, homogeneously …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100–
1,000 nanometres that are shed by cells in response to various physiological and artificial …

One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR),
where cancer cells simultaneously become resistant to different anticancer drugs. Over …

Targeted drug delivery is a promising alternative to overcome the limitations of classical
chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be …

Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration.
Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated …

Multidrug resistance (MDR) in cancer chemotherapy is a growing concern for medical
practitioners. P-glycoprotein (P-gp) overexpression is one of the major reasons for multidrug …

Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy.
The main thing responsible for MDR phenotypes are plasma-membranes associated with …