More than 100 years have passed since the first synthesis and structural recognition of
thioamides. Due to the great practical and synthetic applicability of that class of carboxylic …

Introduction: An epileptic seizure is a transient occurrence of signs and/or symptoms due to
abnormal excessive or synchronous neuronal activity in the brain. The International League …

Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and
electroneutral compounds that block voltage-gated sodium channels. Prior studies have …

Voltage-gated sodium channels (VGSCs) play a central role in the generation and
propagation of action potentials in neurons and other cells. VGSC modulators have their …

Based on the biological importance of the thiazole nucleus, we decided to prepare and
evaluate the biological activity of some new isatin derivatives containing thiazole moiety …

A series of novel 3-{[(substituted phenyl) methyl] thio}-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,
2, 4-triazoles 11–20 and several related Schiff's bases, 3-{[(substituted phenyl)-methyl] thio} …

A series of 6-substituted-[3-substituted-prop-2-eneamido] benzothiazole 9–32 and 6-
substituted-2-[(1-acetyl-5-substituted)-2-pyrazolin-3-yl] aminobenzothiazole 33–56 were …

Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …

Enaminoketones and esters are gaining increased interest, particularly cyclic‐β‐
enaminoesters, which are known as important intermediates for the synthesis of …

In this study, a series of new isatin aroylhydrazones (5a-e and 6a-e) was synthesized and
evaluated for their anticonvulsant activities. The (Z)-configuration of compounds was …