Type 2 diabetes is a complex and heterogeneous disorder presently affecting more than 100
million people worldwide and causing serious socio-economic problems. Appropriate …

The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α
and PPAR-δ, are nuclear receptors that have been the focus of extensive research during …

Lipid abnormalities are among the key risk factors for cardiovascular disease. Indeed, lipid-
modifying drugs—in particular, the statins, which primarily lower plasma levels of low …

PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and
glucose parameters, resulting from an improvement of whole‐body insulin sensitivity …

The peroxisome proliferator-activated receptor γ (PPARγ) is a prototypical member of the
nuclear receptor superfamily and integrates the control of energy, lipid, and glucose …

Objective: The need of today's research is to develop successful and reliable diabetic animal
models for understanding the disease susceptibility and pathogenesis. Enormous success …

The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of fibrate drugs …

Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health
and increasing lifespan. CR exerts its effects through multiple molecular pathways that …

Objective Peroxisome proliferator-activated receptors (PPARs) are key transcription factors
that regulate adipose development and function, and the conversion of white into brown-like …

Patients with type-2 diabetes mellitus (T2DM) are considered to be at particularly high risk
for cardiovascular disease. Over the last decade, the members of the peroxisome proliferator …