T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Genomic investigations of unexplained acute hepatitis in children

S Morfopoulou, S Buddle, OE Torres Montaguth… - Nature, 2023 - nature.com
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK. Here we report an …

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults

HR Wagstaffe, RS Thwaites, A Reynaldi, JK Sidhu… - Science …, 2024 - science.org
Human infection challenge permits in-depth, early, and pre-symptomatic characterization of
the immune response, enabling the identification of factors that are important for viral …

In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms

S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …

Silent battles: immune responses in asymptomatic SARS-CoV-2 infection

N Le Bert, T Samandari - Cellular & Molecular Immunology, 2024 - nature.com
SARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from
asymptomatic infections to severe pneumonia and fatal outcomes. This review centers on …

Defending against SARS-CoV-2: The T cell perspective

P Almendro-Vázquez, R Laguna-Goya… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

Initial immune response after exposure to Mycobacterium tuberculosis or to SARS-COV-2: similarities and differences

A Aiello, S Najafi-Fard, D Goletti - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) and Coronavirus disease-
2019 (COVID-19), whose etiologic agent is severe acute respiratory syndrome coronavirus …

CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment

M Kar, KEE Johnson, A Vanderheiden, EJ Elrod… - Science …, 2024 - science.org
SARS-CoV-2 infection induces the generation of virus-specific CD4+ and CD8+ effector and
memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during …