The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …

Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously
replenish all blood and immune cells during the lifetime of an individual,. HSCs are used …

Wnt signaling pathways and microRNAs (miRNAs) are critical regulators of development.
Aberrant Wnt signaling pathways and miRNA levels lead to developmental defects and …

The Wnt signaling pathway is a highly conserved system that regulates complex biological
processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to …

Background Cancer associated with smoking and drinking remains a serious health
problem worldwide. The survival of patients is very poor due to the lack of effective early …

Background: Accumulating evidence suggests that differentially expressed non-coding
circular RNAs (circRNAs) play critical roles in the progress of autoimmune diseases …