The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a
simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …

The murine neonatal heart can regenerate after injury through cardiomyocyte (CM)
proliferation, although this capacity markedly diminishes after the first week of life …

Decades of progress in developmental cardiology has advanced our understanding of the
early aspects of heart development, including cardiomyocyte (CM) differentiation. However …

Transcription factors are key protein effectors in the regulation of gene transcription, and in
many cases their activity is regulated via a complex network of protein–protein interactions …

The advent of nanomedicine has recently started to innovate the treatment of cardiovascular
diseases, in particular myocardial infarction. Although current approaches are very …

Inflammation is a physiological process by which the body responds to external insults and
stress conditions, and it is characterized by the production of pro-inflammatory mediators …

Background We have shown that genetic overexpression of cell cycle proteins can increase
the proliferation of transplanted cardiomyocytes derived from human induced-pluripotent …

Myocardial infarction results in a massive loss of cardiomyocytes (CMs). Unfortunately,
current therapies are unsuccessful in replacing lost CMs, and thus, there is an urgent need …