Monitoring drug delivery processes by EPR and related techniques—principles and applications

DJ Lurie, K Mäder - Advanced drug delivery reviews, 2005 - Elsevier
Electron Paramagnetic Resonance (EPR, or ESR) is a powerful non-invasive spectroscopic
tool that can be used to monitor drug release processes in vitro and in vivo. Furthermore …

[HTML][HTML] In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques

G Bačić, A Pavićević, F Peyrot - Redox biology, 2016 - Elsevier
Free radicals, particularly reactive oxygen species (ROS), are involved in various
pathologies, injuries related to radiation, ischemia-reperfusion or ageing. Unfortunately, it is …

[图书][B] Nitroxide spin labels: reactions in biology and chemistry

N Kocherginsky, HM Swartz - 1995 - books.google.com
Extending the use of nitroxides as probes into more complex systems such as viable cells
and whole animals requires greater knowledge of their interactions in functioning biological …

Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.

P Kuppusamy, M Chzhan, K Vij… - Proceedings of the …, 1994 - National Acad Sciences
It has been hypothesized that free radical metabolism and oxygenation in living organs and
tissues such as the heart may vary over the spatially defined tissue structure. In an effort to …

Imaging reactive oxygen species-induced modifications in living systems

G Maulucci, G Bačić, L Bridal… - Antioxidants & redox …, 2016 - liebertpub.com
Abstract Significance: Reactive Oxygen Species (ROS) may regulate signaling, ion
channels, transcription factors, and biosynthetic processes. ROS-related diseases can be …

Synthesis and imaging of blood‐brain‐barrier permeable nitroxyl‐probes for free radical reactions in brain of living mice

H Sano, K Matsumoto, H Utsumi - IUBMB Life, 1997 - Wiley Online Library
Three different lipophilic nitroxyl‐probes having capability to pass the blood‐brain barrier
were, for the ftrst time, synthesized to estimate free radical reactions in brain of living …

Cardiac applications of EPR imaging

P Kuppusamy, JL Zweier - NMR in Biomedicine, 2004 - Wiley Online Library
This review summarizes the development and application of a variety of EPR imaging
modalities including spatial, spectral–spatial (spectroscopic), gated‐imaging and oxygen …

High resolution electron paramagnetic resonance imaging of biological samples with a single line paramagnetic label

P Kuppusamy, P Wang, M Chzhan… - Magnetic resonance in …, 1997 - Wiley Online Library
The application of electron paramagnetic resonance imaging (EPRI) to obtain information
from biological samples has been limited by the lack of ideal single line radical labels. The …

Analysis of hepatic oxidative stress status by electron spin resonance spectroscopy and imaging

H Togashi, H Shinzawa, T Matsuo, Y Takeda… - Free Radical Biology …, 2000 - Elsevier
Real-time detection of free radicals generated within the body may contribute to clarify the
pathophysiological role of free radicals in disease processes. Of the techniques available for …

Recent progress in in vivo ESR spectroscopy

K Takeshita, T Ozawa - Journal of radiation research, 2004 - jstage.jst.go.jp
The generation of free radicals and redox status is related to various diseases and injuries
that are related to radiation, aging, ischemia-reperfusion, and other oxidative factors. In vivo …