In health, the near-eucapnic, highly efficient hyperpnea during mild-to-moderate intensity
exercise is driven by three obligatory contributions, namely, feedforward central command …

Rationale: Impaired exercise ventilatory efficiency (high ventilatory requirements for CO2 [V˙
e/V˙ co2]) provides an indication of pulmonary gas exchange abnormalities in chronic …

In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea
generally arises when there is imbalance between ventilatory demand and capacity, but the …

Key points Patients with mild chronic obstructive pulmonary disease (COPD) have an
elevated ventilatory equivalent to CO2 production (/) during exercise, secondary to …

Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease
(COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non …

Background and objective The combination of both reduced resting diffusing capacity of the
lung for carbon monoxide (DLCO) and ventilatory efficiency (increased ventilatory …

Patients with mild chronic obstructive pulmonary disease (COPD) and lower resting diffusing
capacity for carbon monoxide (DLCO) often report troublesome dyspnea during exercise …

Following pulmonary embolism (PE), a third of patients develop persistent dyspnea, which is
commonly termed the post-PE syndrome. The neurophysiological underpinnings of …

There is growing recognition that a sizable fraction of COPD patients with forced expiratory
volume in one second (FEV1)/forced vital capacity ratio below the lower limit of normal but …

We tested the hypothesis that increasing the respiratory control systems' arterial PCO 2
equilibrium point via induced acute metabolic alkalosis by ingestion of sodium bicarbonate …