Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
Mitochondrial dysfunction in Parkinson's disease: new mechanistic insights and therapeutic perspectives
Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …
[HTML][HTML] Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms
Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …
[HTML][HTML] Metals and neurodegeneration
Metals play important roles in the human body, maintaining cell structure and regulating
gene expression, neurotransmission, and antioxidant response, to name a few. However …
gene expression, neurotransmission, and antioxidant response, to name a few. However …
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
Y Li, Y Du, Y Zhou, Q Chen, Z Luo, Y Ren… - Cell Communication and …, 2023 - Springer
Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling
cascades and molecular mechanisms. RCD is implicated in fundamental processes such as …
cascades and molecular mechanisms. RCD is implicated in fundamental processes such as …
Ferroptosis and its multifaceted roles in cerebral stroke
Y Zhang, X Lu, B Tai, W Li, T Li - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and
distinct biological features compared with other well-known programmed cell death …
distinct biological features compared with other well-known programmed cell death …
The multifaceted regulation of mitochondria in ferroptosis
H Wu, F Wang, N Ta, T Zhang, W Gao - Life, 2021 - mdpi.com
Ferroptosis is characterized as a novel form of regulated cell death, which is initiated by the
lethal accumulation of lipid peroxidation catalyzed by cellular labile free iron. This iron …
lethal accumulation of lipid peroxidation catalyzed by cellular labile free iron. This iron …
Mitochondrial iron in human health and disease
DM Ward, SM Cloonan - Annual review of physiology, 2019 - annualreviews.org
Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria
encompass an active organellar network that fuses, divides, and directs a myriad of vital …
encompass an active organellar network that fuses, divides, and directs a myriad of vital …
Mitochondrial iron metabolism and neurodegenerative diseases
Iron is a key element for mitochondrial function and homeostasis, which is also crucial for
maintaining the neuronal system, but too much iron promotes oxidative stress. A large body …
maintaining the neuronal system, but too much iron promotes oxidative stress. A large body …
Iron dysregulation in mitochondrial dysfunction and Alzheimer's disease
JO Onukwufor, RT Dirksen, AP Wojtovich - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD) is a devastating progressive neurodegenerative disease
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …
characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron …