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Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Hurdles exist to clinical xenotransplantation including potential infectious transmission from
nonhuman species to xenograft recipients. In anticipation of clinical trials of …

Islet transplantation represents a most impressive recent advance in the search for a type 1
diabetes mellitus cure. While several hundred patients have achieved at least temporary …

Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect
certain human cells and therefore pose a special risk for xenotransplantation using pig cells …

Background: Xenotransplantation using porcine cells, tissues or organs may be associated
with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral …

Xenotransplantation is a possible solution for the shortage of tissues for human
transplantation. Multiple hurdles exist to clinical xenotransplantation, including immunologic …

Xenotransplantation of porcine tissues has the potential to treat a wide variety of major
health problems including organ failure and diabetes. Balanced against the potential …

Here we report the identification of inbred miniature swine that failed to produce human-
tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro …

Post‐transplantation infections are common. In immunosuppressed human xenograft
recipients, infection is most likely to be due to the same pathogens seen in human …