Anastomotic leak (AL) constitutes a significant issue in colorectal surgery, and its incidence
has remained stable over the last years. The use of intra-abdominal drain or the use of …

Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic
steatohepatitis (NASH) have emerged as the leading causes of chronic liver disease-related …

Background and Aims DNA damage‐induced NF‐κB activation is a major obstacle to
effective antitumour chemotherapy. Long noncoding RNAs (lncRNAs) that regulate …

Background & Aims Primary liver cancers include hepatocellular carcinoma (HCC),
intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It …

Background: Treatment with the chemotherapy drug doxorubicin (DOX) may lead to
toxicities that affect non-cancer cells including the liver. Supplementing the diet with creatine …

Abstract Treatment of primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) is
not always sufficient to prevent progression to hepatic decompensation and/or need for liver …

Gradual alterations of cell's physiology and functions due to age or exposure to various
stresses lead to the conversion of normal cells to senescent cells. Once becoming …

Background and Aims Acetaminophen (APAP) overdose induces severe liver injury and
hepatic failure. While the activation of c‐Jun NH2‐terminal kinase (JNK) has been …

Cellular senescence is an irreversible cell cycle arrest implemented by the cell as a result of
stressful insults. Characterized by phenotypic alterations, including secretome changes and …

Cholangiocytes are the target of a group of chronic liver diseases termed the
“cholangiopathies,” in which cholangiocytes react to exogenous and endogenous insults …