We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

DNA fragmentation is an important factor in the aetiology of male infertility. However, it is still
underevaluated and its inclusion in routine semen analysis is debated. DNA fragmentation …

The preservation of genome integrity in the mammalian female germline from primordial
follicle arrest to activation of growth to oocyte maturation is fundamental to ensure …

A systematic review and meta-analysis was conducted to evaluate the relationship between
the extent of sperm DNA damage and live birth rate (LBR) per couple and the influence of …

Reactive oxygen species (ROS) generated at low levels during mitochondrial respiration
have key roles in several signaling pathways. Oxidative stress (OS) arises when the …

Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body
respond differentially to DNA damage. In this review, we will discuss how different SC …

Reproductive diseases have become a growing worldwide problem and male factor plays
an important role in the reproductive diagnosis, prognosis and design of assisted …

The genome of all cells is protected at all times by mechanisms collectively known as DNA
repair activity (DRA). Such activity is particularly important at the beginning of human life, ie …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …