The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality worldwide,
develops almost exclusively in patients with chronic liver disease and advanced fibrosis …

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Abstract β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion
molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins) …

Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …

Summary ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer
and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …

Interleukin‐6 (IL‐6) is critically involved in liver regeneration after partial hepatectomy (PHX).
Previous reports suggest that IL‐6 trans‐signaling through the soluble IL‐6/IL‐6R complex is …