Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel
It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …
Fibroblast growth factor 2 as an antifibrotic: antagonism of myofibroblast differentiation and suppression of pro-fibrotic gene expression
Fibrosis is a pathological condition that is characterized by the replacement of dead or
damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies …
damaged tissue with a nonfunctional, mechanically aberrant scar, and fibrotic pathologies …
ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Background Angiogenesis plays an important role in the survival of tissues, as blood vessels
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane
J Wang, DA Richards - Biology open, 2012 - journals.biologists.com
PIP2 and PIP3 are implicated in a wide variety of cellular signaling pathways at the plasma
membrane. We have used STORM imaging to localize clusters of PIP2 and PIP3 to distinct …
membrane. We have used STORM imaging to localize clusters of PIP2 and PIP3 to distinct …
[HTML][HTML] Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
S Tauzin, B Chaigne-Delalande, E Selva, N Khadra… - PLoS …, 2011 - journals.plos.org
Patients affected by chronic inflammatory disorders display high amounts of soluble CD95L.
This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane …
This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane …
Role of phospholipase C in cell invasion and metastasis
R Lattanzio, M Piantelli, M Falasca - Advances in biological regulation, 2013 - Elsevier
Phospholipases are enzymes that use phospholipids as substrate and are classified in three
major classes A, C and D based on the reaction they catalyse. Phosphatidylinositol-specific …
major classes A, C and D based on the reaction they catalyse. Phosphatidylinositol-specific …
Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling
Polycystic kidney disease (PKD) is a common cause of renal failure with few effective
treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates …
treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates …
A synthesis, in silico, in vitro and in vivo study of thieno [2, 3-b] pyridine anticancer analogues
HJ Arabshahi, M Van Rensburg, LI Pilkington… - …, 2015 - pubs.rsc.org
The anticancer activity of the thieno [2, 3-b] pyridines was explored by altering the ring size
of the cyclo-aliphatic moiety. Five-, six-, seven-and eight-membered derivatives were tested …
of the cyclo-aliphatic moiety. Five-, six-, seven-and eight-membered derivatives were tested …
Histone demethylase KDM5C drives prostate cancer progression by promoting EMT
AL Lemster, E Sievers, H Pasternack, P Lazar-Karsten… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer is the most common cancer in men and is one of the
leading causes of cancer-related deaths. During prostate cancer progression and …
leading causes of cancer-related deaths. During prostate cancer progression and …