[HTML][HTML] Building blocks of microphysiological system to model physiology and pathophysiology of human heart
H Vuorenpää, M Björninen, H Välimäki, A Ahola… - Frontiers in …, 2023 - frontiersin.org
Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …
biomedical industry due to their improved capability to capture human physiology. MPS offer …
[HTML][HTML] Methods for in vitro functional analysis of iPSC derived cardiomyocytes—Special focus on analyzing the mechanical beating behavior
A rapidly increasing number of papers describing novel iPSC models for cardiac diseases
are being published. To be able to understand the disease mechanisms in more detail, we …
are being published. To be able to understand the disease mechanisms in more detail, we …
[HTML][HTML] Image-based evaluation of contraction–relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity …
T Hayakawa, T Kunihiro, T Ando, S Kobayashi… - Journal of molecular and …, 2014 - Elsevier
In this study, we used high-speed video microscopy with motion vector analysis to
investigate the contractile characteristics of hiPS-CM monolayer, in addition to further …
investigate the contractile characteristics of hiPS-CM monolayer, in addition to further …
Matrigel mattress: a method for the generation of single contracting human-induced pluripotent stem cell–derived cardiomyocytes
Rationale: The lack of measurable single-cell contractility of human-induced pluripotent
stem cell–derived cardiac myocytes (hiPSC-CMs) currently limits the utility of hiPSC-CMs for …
stem cell–derived cardiac myocytes (hiPSC-CMs) currently limits the utility of hiPSC-CMs for …
[HTML][HTML] A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing
M Maddah, JD Heidmann, MA Mandegar, CD Walker… - Stem cell reports, 2015 - cell.com
We present a non-invasive method to characterize the function of pluripotent stem-cell-
derived cardiomyocytes based on video microscopy and image analysis. The platform …
derived cardiomyocytes based on video microscopy and image analysis. The platform …
[HTML][HTML] Xeno-and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method
H Hongisto, T Ilmarinen, M Vattulainen… - Stem cell research & …, 2017 - Springer
Background Human pluripotent stem cells (hPSCs) provide a promising cell source for
ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture …
ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture …
[HTML][HTML] Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform
YC Tsan, SJ DePalma, YT Zhao, A Capilnasiu… - Nature …, 2021 - nature.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) allow investigations in a
human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on …
human cardiac model system, but disorganized mechanics and immaturity of hPSC-CMs on …
Mechanically biomimetic gelatin–gellan gum hydrogels for 3D culture of beating human cardiomyocytes
To promote the transition of cell cultures from 2D to 3D, hydrogels are needed to biomimic
the extracellular matrix (ECM). One potential material for this purpose is gellan gum (GG), a …
the extracellular matrix (ECM). One potential material for this purpose is gellan gum (GG), a …
[HTML][HTML] All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation
High-throughput in vitro drug assays have been impacted by recent advances in human
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact …
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact …
Mutation‐Specific Phenotypes in hiPSC‐Derived Cardiomyocytes Carrying Either Myosin‐Binding Protein C Or α‐Tropomyosin Mutation for Hypertrophic …
M Ojala, C Prajapati, RP Pölönen… - Stem cells …, 2016 - Wiley Online Library
Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure
of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure …
of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure …