The search for novel anti-infectives is one of the most important challenges in natural
product research, as diseases caused by bacteria, viruses, and fungi are influencing the …

Phylogenetic analysis of 11 genetic loci and results from many genotyping studies revealed
significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus …

Abstract SARS coronavirus-2 (SARS-CoV-2) detection in different clinical specimens has
raised important insights about its pathogenesis, but some details remain to be understood …

This account exemplifies our recent progress on the strategic incorporation of fluorine and
organofluorine groups to (i) taxoid anticancer agents,(ii) acylhydrazone-based antifungal …

Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …

Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …

Iron is a key transition metal required by most microorganisms and is prominently utilised in
the transfer of electrons during metabolic reactions. The acquisition of iron is essential and …

This analysis aimed to characterize the epidemiology, diagnosis, treatment, and outcomes of
invasive fungal infections (IFIs) in patients with human immunodeficiency virus (HIV). Data …

Background. Cryptococcal meningitis (CM) is one of the most common causes of AIDS-
related mortality worldwide, accounting for 33%–63% of all cases of adult meningitis in sub …

The hyper IgM syndromes are a rare group of primary immunodeficiency. The X-linked
Hyper IgM syndrome (HIGM), due to a gene defect in CD40L, is the commonest variant; it is …