Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …

Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now
appreciated that somatic missense mutations in histones, the packaging agents of genomic …

The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Patients with diffuse midline gliomas that are H3K27 altered (DMG) display a dismal
prognosis. However, the molecular mechanisms underlying DMG tumorigenesis remain …

Diffuse midline gliomas (DMGs) are devastating pediatric brain tumors recognized as the
leading cause of cancer-related death in children. DMGs are high-grade gliomas (HGGs) …

Simple Summary Diffuse intrinsic pontine glioma (DIPG) is a malignant primary glial tumor
that occurs in all age groups but predominates in children and is estimated to account for …

Cancer-associated mutations in genes encoding histones dramatically reshape chromatin
and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 …

Aberrant cell fate decisions due to transcriptional misregulation are central to malignant
transformation. Histones are the major constituents of chromatin, and mutations in histone …

High-grade glioma (HGG) is the most common cause of cancer death in children and the
most common primary central nervous system tumor in adults. While pediatric HGG was …

There is an ongoing debate regarding whether gliomas originate due to functional or genetic
changes in neural stem cells (NSCs). Genetic engineering has made it possible to use …