Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis

L Rohmer, D Hocquet, SI Miller - Trends in microbiology, 2011 - cell.com
It is interesting to speculate that the evolutionary drive for microbes to develop pathogenic
characteristics was to access the nutrient resources that animals provided. Animal …

Transporters of glucose and other carbohydrates in bacteria

JM Jeckelmann, B Erni - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
Glucose arguably is the most important energy carrier, carbon source for metabolites and
building block for biopolymers in all kingdoms of life. The proper function of animal organs …

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence

B Steeb, B Claudi, NA Burton, P Tienz, A Schmidt… - PLoS …, 2013 - journals.plos.org
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth
and virulence, disease progression, and infection control. However, our understanding of …

Salmonella enterica remodels the host cell endosomal system for efficient intravacuolar nutrition

V Liss, AL Swart, A Kehl, N Hermanns, Y Zhang… - Cell host & …, 2017 - cell.com
Salmonella enterica is a facultative intracellular pathogen that survives and proliferates in
the Salmonella-containing vacuole (SCV), yet how these vacuolar bacteria acquire nutrition …

Microbial functional structure of Montastraea faveolata, an important Caribbean reef‐building coral, differs between healthy and yellow‐band diseased colonies

NE Kimes, JD Van Nostrand, E Weil… - Environmental …, 2010 - Wiley Online Library
A functional gene array (FGA), GeoChip 2.0, was used to assess the biogeochemical cycling
potential of microbial communities associated with healthy and Caribbean yellow band …

Navigating the gut buffet: Control of polysaccharide utilization in Bacteroides spp.

ND Schwalm, EA Groisman - Trends in Microbiology, 2017 - cell.com
Bacteroides spp. are members of the human gut microbiota that confer myriad benefits on
their hosts. Among them is the provision of energy from otherwise indigestible …

Small RNA functions in carbon metabolism and virulence of enteric pathogens

K Papenfort, J Vogel - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Enteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these
frequent changes in nutrient availability and composition bacteria possess an arsenal of …

Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery

M Tong, ED Brown - Annals of the New York Academy of …, 2023 - Wiley Online Library
Antimicrobial resistance is at an all‐time high and new drugs are required to overcome this
crisis. Traditional approaches to drug discovery have failed to produce novel classes of …

Metabolic sensor governing bacterial virulence in Staphylococcus aureus

Y Ding, X Liu, F Chen, H Di, B Xu… - Proceedings of the …, 2014 - National Acad Sciences
An effective metabolism is essential to all living organisms, including the important human
pathogen Staphylococcus aureus. To establish successful infection, S. aureus must …

Preferential Use of Central Metabolism In Vivo Reveals a Nutritional Basis for Polymicrobial Infection

CJ Alteri, SD Himpsl, HLT Mobley - PLoS pathogens, 2015 - journals.plos.org
The human genitourinary tract is a common anatomical niche for polymicrobial infection and
a leading site for the development of bacteremia and sepsis. Most uncomplicated …