The purpose of this work is to review the published strategies for the production of prodrugs
of amines. The review is divided in two main groups of approaches: those that rely on …

Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in
xenobiotic, drug, and lipid metabolism in the body and are members of at least five gene …

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-
11) in the treatment against colorectal cancer and also has some relationship with the side …

Irinotecan-based therapy is a common treatment for pancreatic cancer. To elicit its
anticancer activity, the drug requires first the hydrolysis action of the enzyme human …

As the most important members of serine esterase hydrolase superfamily, mammalian
carboxylesterases (CESs) are widely distributed in various tissues like liver, intestine, lung …

Importance of the field: Emerging evidence demonstrates that several nuclear receptor (NR)
family members regulate drug-inducible expression and activity of several important …

Novel anticancer compounds and their precision delivery systems are actively developed to
create potent and well‐tolerated anticancer therapeutics. Here, we report the synthesis of a …

Colloidal drug aggregates have been a nuisance in drug screening, yet, because they
inherently comprise drug-rich particles, they may be useful in vivo if issues of stability can be …

Orlistat has been the most used anti-obesity drug and the mechanism of its action is to
reduce lipid absorption by inhibiting gastrointestinal lipases. These enzymes, like …

Doxazolidine (doxaz) is a new anthracycline anticancer agent. While structurally similar to
doxorubicin (dox), doxaz acts via a distinct mechanism to selectively enhance anticancer …