Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma
A Barzegar Behrooz, Z Talaie, F Jusheghani… - International journal of …, 2022 - mdpi.com
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
More friend than foe: the emerging role of neutrophils in tissue repair
M Peiseler, P Kubes - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …
Understanding Fc receptor involvement in inflammatory diseases: from mechanisms to new therapeutic tools
S Ben Mkaddem, M Benhamou… - Frontiers in …, 2019 - frontiersin.org
Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …
and innate immunity which are essential for appropriate responses to infections and …
PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer
FE Marquard, M Jücker - Biochemical pharmacology, 2020 - Elsevier
The aim of this review is to summarize current available information about the role of
PI3K/AKT/mTOR signaling in head and neck cancer as a potential target for new therapy …
PI3K/AKT/mTOR signaling in head and neck cancer as a potential target for new therapy …
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
SR Nielsen, V Quaranta, A Linford, P Emeagi… - Nature cell …, 2016 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which
better therapies are urgently needed. Macrophages enhance metastasis in many cancer …
better therapies are urgently needed. Macrophages enhance metastasis in many cancer …
[HTML][HTML] PI3K signalling in inflammation
PT Hawkins, LR Stephens - … et Biophysica Acta (BBA)-Molecular and Cell …, 2015 - Elsevier
PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …
NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
C Guo, R Fu, S Wang, Y Huang, X Li… - Clinical & …, 2018 - academic.oup.com
Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain
containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility …
containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility …
PI3K signalling: the path to discovery and understanding
B Vanhaesebroeck, L Stephens… - Nature reviews Molecular …, 2012 - nature.com
Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has
progressed from the identification of an enzymatic activity associated with growth factors …
progressed from the identification of an enzymatic activity associated with growth factors …
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
JB Baell, GA Holloway - Journal of medicinal chemistry, 2010 - ACS Publications
This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …