Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

INTRODUCTION In all eukaryotic cells, lipid droplets (LDs) store and supply essential lipids
to produce signaling molecules, membrane building blocks, and metabolic energy. The LD …

Biomarker research is continuously expanding in the field of clinical proteomics. A
combination of different proteomic–based methodologies can be applied depending on the …

The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of
proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs) …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

Consistent and accurate quantification of proteins by mass spectrometry (MS)-based
proteomics depends on the performance of instruments, acquisition methods and data …

Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-
related deaths resulting from myocardial infarction or stroke. The main underlying cause of …

Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and
type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1 receptor (GLP-1R) and …

Mesenchymal stem cells have previously been shown to mediate brain repair after stroke;
they secrete 50–100 nm complexes called extracellular vesicles (EVs), which could be …