The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T
cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must …

The thymus is a primary lymphoid organ constituted by a 3D epithelial network that provides
a specialized microenvironment in which seeding lymphoid progenitors undergo …

Age-associated thymus involution results in decreased generation and export of T cells, with
an associated increase in susceptibility to pathogens. Elucidating mechanisms underlying …

T cells are integral to the adaptive immune response against foreign pathogens and tumor
cells. They respond to foreign substances, termed antigens, that can elicit immune …