The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

The gut microbiota shapes the response to immune checkpoint inhibitors (ICIs) in cancer,
however dietary and geographic influences have not been well-studied in prospective trials …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes
and functions that are influenced by the microbiota. These cells play pivotal parts in the …

Autoimmune diseases are a result of the immune system being misdirected toward its host
and have major and increasing unmet clinical needs. In general, present therapies are …

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis
point to distinct immunological pathways that drive disease relapses and progression. In …