Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
CE Stewart, P Rotwein - Physiological reviews, 1996 - journals.physiology.org
The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
Genomic imprinting in mammals
MS Bartolomei, SM Tilghman - Annual review of genetics, 1997 - annualreviews.org
▪ Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent
state from one of the two parents, and in a fully active form from the other, thereby rendering …
state from one of the two parents, and in a fully active form from the other, thereby rendering …
Genetic and epigenetic basis of hepatoblastoma diversity
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary
predisposition and acquired molecular aberrations related to HB clinicopathological …
predisposition and acquired molecular aberrations related to HB clinicopathological …
[图书][B] Chromosome abnormalities and genetic counseling
RJMK Gardner, GR Sutherland, LG Shaffer - 2012 - books.google.com
Chromosome abnormalities have been known for over 50 years, though the methods of
analysis have become increasing more sophisticated and precise. Surprisingly, the …
analysis have become increasing more sophisticated and precise. Surprisingly, the …
UBE3A/E6-AP mutations cause Angelman syndrome
T Kishino, M Lalande, J Wagstaff - Nature genetics, 1997 - nature.com
Angelman syndrome (AS), characterized by mental retardation, seizures, frequent smiling
and laughter, and abnormal gait, is one of the best examples of human disease in which …
and laughter, and abnormal gait, is one of the best examples of human disease in which …
Paternally Inherited IGF2 Mutation and Growth Restriction
M Begemann, B Zirn, G Santen… - … England Journal of …, 2015 - Mass Medical Soc
In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction;
however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking …
however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking …
[HTML][HTML] Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction
Purpose Fetal growth is a complex process involving maternal, placental and fetal factors.
The etiology of fetal growth retardation remains unknown in many cases. The aim of this …
The etiology of fetal growth retardation remains unknown in many cases. The aim of this …
IGF2 signaling and regulation in cancer
J Brouwer-Visser, GS Huang - Cytokine & growth factor reviews, 2015 - Elsevier
Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …
is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is …
Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site
GA Ulaner, TH Vu, T Li, JF Hu, XM Yao… - Human molecular …, 2003 - academic.oup.com
The adjacent insulin-like growth factor 2 (IGF2) and H19 genes are imprinted in most normal
human tissues, but imprinting is often lost in tumors. The mechanisms involved in …
human tissues, but imprinting is often lost in tumors. The mechanisms involved in …
[HTML][HTML] CircHMGCS1 promotes hepatoblastoma cell proliferation by regulating the IGF signaling pathway and glutaminolysis
N Zhen, S Gu, J Ma, J Zhu, M Yin, M Xu, J Wang… - Theranostics, 2019 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs), a novel class of endogenous RNAs, have been recently shown to
participate in cellular development and several pathophysiological processes. The …
participate in cellular development and several pathophysiological processes. The …