Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural
products are being developed as promising therapeutic approaches. Gracillin is a naturally …

Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare.
Here we describe Gboxin, a small molecule that specifically inhibits the growth of primary …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

Organotin (IV) compounds have wide applications in industrial and agricultural fields owing
to their ability to act as poly (vinyl chloride) stabilizers and catalytic agents as well as their …

Seven rhenium (I) complexes of the general formula fac-[Re (CO) 3 (NN)(OH2)]+ where NN=
2, 2′-bipyridine (8), 4, 4′-dimethyl-2, 2′-bipyridine (9), 4, 4′-dimethoxy-2, 2′-bipyridine …

The incidences of cancer are continuously increasing worldwide, affecting life of millions of
people. Several factors associated with the internal and external environment are …

Most small molecule drugs interact with unintended, often unknown, biological targets and
these off-target interactions may lead to both preclinical and clinical toxic events. Undesired …

Background Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in
clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial …

Selenium is a trace element that has been shown to inhibit the growth of various cancer cell
types. However, its role in cervical cancer and its underlying mechanisms remains largely …