Increased understanding of the role of protein-and lipid-linked carbohydrates in a wide
range of biological processes has led to interest in drugs that target the enzymes involved in …

Numerous numbers of biologically active agents have been identified for their diverse
therapeutic functions. Detailed investigations of phytochemicals for antiviral activities have …

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid
membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives …

Endoplasmic reticulum (ER) α-glucosidase inhibitors, which block the trimming step of N-
linked glycosylation, have been shown to eliminate the production of several ER-budding …

Over the past few years, the number of people diagnosed with type 2 diabetes has
increased owing to an unhealthy diet, a limited amount of exercise, and obesity. The search …

Enveloped viruses have developed various adroit mechanisms to invade their host cells.
This process requires one or more viral envelope glycoprotein to achieve cell attachment …

Chronic infection with hepatitis C virus (HCV) is an emerging global epidemic. The
development of effective HCV antiviral therapeutics continues to be a daunting challenge …

The therapeutic options for lysosomal storage diseases (LSDs) have expanded greatly over
the past decade, although for many disorders there is still no effective treatment. Given that …

Iminosugars have emerged in the literature during mid-1960's as synthetic compounds.
Around the same time, the first examples were found in Nature and their interesting enzyme …

Glycosylation as one of most important post-translational modification of gene products is
often critical to specific cellular biological functions. Since elevated glycoprocessing enzyme …