[HTML][HTML] Pulmonary immune dysregulation and viral persistence during HIV infection
Y Alexandrova, CT Costiniuk, MA Jenabian - Frontiers in immunology, 2022 - frontiersin.org
Despite the success of antiretroviral therapy (ART), people living with HIV continue to suffer
from high burdens of respiratory infections, lung cancers and chronic lung disease at a …
from high burdens of respiratory infections, lung cancers and chronic lung disease at a …
[HTML][HTML] Defective HIV-1 genomes and their potential impact on HIV pathogenesis
J Kuniholm, C Coote, AJ Henderson - Retrovirology, 2022 - Springer
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2
R Amraei, W Yin, MA Napoleon, EL Suder… - ACS Central …, 2021 - ACS Publications
As the COVID-19 pandemic continues to spread, investigating the processes underlying the
interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the …
interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the …
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells
SARS-CoV-2 entry into host cells is a crucial step for virus tropism, transmission, and
pathogenesis. Angiotensin-converting enzyme 2 (ACE2) has been identified as the primary …
pathogenesis. Angiotensin-converting enzyme 2 (ACE2) has been identified as the primary …
[HTML][HTML] CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine
expression is thought to be a major driver of chronic COVID-19 pathology. Although …
expression is thought to be a major driver of chronic COVID-19 pathology. Although …
[HTML][HTML] N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages
N 6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in
regulating eukaryotic cellular mRNA functions. RNA m6A modification is regulated by two …
regulating eukaryotic cellular mRNA functions. RNA m6A modification is regulated by two …
Sec24C is an HIV-1 host dependency factor crucial for virus replication
Early events of the human immunodeficiency virus 1 (HIV-1) lifecycle, such as post-entry
virus trafficking, uncoating and nuclear import, are poorly characterized because of limited …
virus trafficking, uncoating and nuclear import, are poorly characterized because of limited …
[HTML][HTML] Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity
G Sannier, M Dube, C Dufour, C Richard, N Brassard… - Cell reports, 2021 - cell.com
Although understanding the diversity of HIV-1 reservoirs is key to achieving a cure, their
study at the single-cell level in primary samples remains challenging. We combine flow …
study at the single-cell level in primary samples remains challenging. We combine flow …
[HTML][HTML] HIV persistence: silence or resistance?
AO Pasternak, B Berkhout - Current opinion in virology, 2023 - Elsevier
Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
[HTML][HTML] Sensor sensibility—HIV-1 and the innate immune response
Innate immunity represents the human immune system's first line of defense against a
pathogenic intruder and is initiated by the recognition of conserved molecular structures …
pathogenic intruder and is initiated by the recognition of conserved molecular structures …