Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Siglecs are a family of sialic acid–binding receptors expressed by cells of the immune
system and a few other cell types capable of modulating immune cell functions upon …

The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant
clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies …

A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

Siglecs (sialic acid-binding immunoglobulin-type lectins) are a family of immune regulatory
receptors predominantly found on the cells of the hematopoietic system. A V-set Ig-like …

Epithelial ovarian cancer (EOC) often presents with metastases and ascites. Granulocytic
myeloid–derived suppressor cells are an immature population that impairs antitumor …

Introduction: During cancer progression, tumor cells develop several mechanisms to prevent
killing and to shape the immune system into a tumor-promoting environment. One of such …

Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-
2, are characterized by a hyperinflammatory immune response that leads to numerous …