Biological Properties, Bioactive Constituents, and Pharmacokinetics of Some Capsicum spp. and Capsaicinoids
GES Batiha, A Alqahtani, OA Ojo, HM Shaheen… - International journal of …, 2020 - mdpi.com
Pepper originated from the Capsicum genus, which is recognized as one of the most
predominant and globally distributed genera of the Solanaceae family. It is a diverse genus …
predominant and globally distributed genera of the Solanaceae family. It is a diverse genus …
Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
V Fattori, MSN Hohmann, AC Rossaneis… - Molecules, 2016 - mdpi.com
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
The vanilloid receptor: a molecular gateway to the pain pathway
MJ Caterina, D Julius - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …
Unravelling the mystery of capsaicin: a tool to understand and treat pain
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …
physiological systems, with an emphasis on pain research but also including functions such …
Modified formalin test: characteristic biphasic pain response
M Shibata, T Ohkubo, H Takahashi, R Inoki - pain, 1989 - Elsevier
A modified formalin test in mice was investigated. The pain response curve induced by 0.5%
formalin was biphasic, having 2 peaks, from 0 to 5 min (first phase) and from 15 to 20 min …
formalin was biphasic, having 2 peaks, from 0 to 5 min (first phase) and from 15 to 20 min …
Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
P Holzer - Neuroscience, 1988 - Elsevier
5. LOCAL EFFECTOR FUNCTIONS OF SENSORY NERVE ENDINGS 743 50.1. Antidromic
Vas~ iIatation, neurogenic inflammation and axon refk~ 5.0. 2. The type of sensory neurons …
Vas~ iIatation, neurogenic inflammation and axon refk~ 5.0. 2. The type of sensory neurons …
The neurobiology of vascular head pain
MA Moskowitz - Annals of Neurology: Official Journal of the …, 1984 - Wiley Online Library
Nervous connections between the trigeminal ganglia and cerebral blood vessels have
recently been identified in experimental animals and have been termed the …
recently been identified in experimental animals and have been termed the …
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum
fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been …
fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been …