Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Mechanosensation is the ability to detect dynamic mechanical stimuli (eg, pressure, stretch,
and shear stress) and is essential for a wide variety of processes, including our sense of …

TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate
immune cells encounter different mechanical cues in both health and disease to adapt their …

Alteration of tissue mechanical properties is a physical hallmark of solid tumors including
gliomas. How tumor cells sense and regulate tissue mechanics is largely unknown. Here …

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high
shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Many tissues harbor quiescent stem cells that are activated upon injury, subsequently
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

YAP and TAZ are ubiquitously expressed homologous proteins originally identified as
penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining …