Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-
band region. Various structural, signaling, and mechanical functions have been associated …

Titin has long been recognized as a mechanical protein in muscle cells that has a main
function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests …

This review will provide a comprehensive, up-to-date review of the current knowledge
regarding the pathophysiology of muscle contractures in cerebral palsy. Although much has …

The delivery of mechanical power, a crucial component of animal motion, is constrained by
the universal compromise between the force and the velocity of its constituent molecular …

Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated
muscle organelles that are comprised of sarcomeres that are strictly aligned in series …

Studies of muscle structure and function can be traced to at least 2,000 years ago. However,
the modern era of muscle contraction mechanisms started in the 1950s with the classic …

The periodic striation pattern in skeletal muscle reflects the length of the basic contractile
unit: the sarcomere. More than half a century ago, Gordon, Huxley and Julian provided …

The peculiar attributes of muscles that are stretched when active have been noted for nearly
a century. Understandably, the focus of muscle physiology has been primarily on shortening …

Gaps in our understanding of muscle mechanics demonstrate that the current model is
incomplete. Increasingly, it appears that a role for titin in active muscle contraction might …

The cross-bridge theory predicts that muscle force is determined by muscle length and the
velocity of active muscle length changes. However, before the formulation of the cross …