One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …

The accumulation of leukocytes in inflamed tissue results from adhesive interactions
between leukocytes and endothelial cells within the microcirculation. These adhesive …

Reperfusion of ischemic myocardium is necessary to salvage tissue from eventual death.
However, reperfusion after even brief periods of ischemia is associated with pathologic …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

The microcirculation undergoes a profound degree of endothelial dysfunction within minutes
(ie, 2.5 to 5 min) following reperfusion of ischaemic vasculature. This has been documented …

In the intact organism, ischemic myocardial injury initiates an acute inflammatory response
in which polymorphonuclear leukocytes (PMNs) are major participants. Evidence indicates …

▪ Abstract An effective host response to infection or tissue damage requires focal
accumulation of leukocytes. Leukocyte adhesion to the vessel wall, a key step in this …

Myocardial infarction triggers an inflammatory cascade that results in healing and
replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate …