The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Genomic instability consists of a range of genetic alterations within the genome that
contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …

Kinetochores are multiprotein assemblies directing mitotic spindle attachment and
chromosome segregation. In apicomplexan parasites, most known kinetochore components …

In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that
exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Faithful meiotic progression ensures the generation of viable gametes. Studies suggested
the male meiosis of plants is sensitive to ambient temperature, but the underlying molecular …

The close-knit group of apicomplexan parasites displays a wide variety of cell division
modes, which differ between parasites as well as between different life stages within a …

Cells replicate and segregate their DNA with precision. Previous studies showed that these
regulated cell-cycle processes were present in the last eukaryotic common ancestor and that …