Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …

Solid tumours are composed of cancer cells characterised by genetic mutations that
underpin the disease, but also contain a suite of genetically normal cells and the …

Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Simple Summary Classic histopathological examination of tissues remains the mainstay for
cancer diagnosis and staging. However, in some cases histopathologic analysis yields …

In the tumor microenvironment (TME), the extracellular matrix (ECM) produced by cancer-
associated fibroblasts (CAFs) forms a dense barrier that prevents nanodrugs from …

Breast cancer (BC) is one of the most heterogeneous groups of cancer. As every biotype of
BC is unique and presents a particular “omic” signature, they are increasingly characterized …

Proteomics continues to forge significant strides in the discovery of essential biological
processes, uncovering valuable information on the identity, global protein abundance …

Simple Summary The childhood tumor, neuroblastoma, has a broad clinical presentation.
Risk assessment at diagnosis is particularly difficult in molecularly heterogeneous high-risk …

MALDI mass spectrometry imaging (MALDI imaging) uniquely advances cancer research, by
measuring spatial distribution of endogenous and exogenous molecules directly from tissue …

The extracellular matrix (ECM) proteome represents an important component of the tissue
microenvironment that controls chemical flux and induces cell signaling through encoded …